Layers of CD4 T cell immunity in HIV infection

• 作 者: Hendrik Streeck
• 机 构: InstituteforMedicalBiology,UniversityHospitalEssen,UniversityDuisburg-Essen,Essen,Germany
• 出 处: 第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
• 发表日期: 2015年10期

CD4 T cells are the major target of HIV and progressively lost during infection.However,emerging data suggest that HIV-specific CD4 T cell responses significantly contribute to the antiviral immune response.Indeed,the breadth and magnitude of HIV-specific IFNγ+ CD4 T cells and especially those with cytolytic functions have been associated with better disease outcome.