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Vasculogenesis and Angiogenesis are complex processes, which involves amultidisciplinary orchestration between diverse angiogenic factors, cytokines, proteases andmechanical factors.Although several angiogenic and angiostatic factors such as vascular endothelial growth factor (VEGF), Angiopoietin (Ang), bFGF, Integrins, Insulin like growth factor (IGF-1), Placental growth factor (PlGF), TGF, PDGF, TNF, matrix-metalloproteases (MMPs), VECadherin, CXCchemokines play a role, VEGF is recognised as the most prominent, promising and potent angiogenic factor.VEGF is a heparin-binding glycoprotein and an endothelial cell mitogen which causes an increase in vascular permeability.VEGF is the prototypieal member of a family of angiogenic factors which include PlGF and VEGF A,B, C, D, E.Most regulate physiological and pathological angiogenesis.Human VEGF-A (referred as VEGF) is expressed in multiple protein isoforms (121, 145, 165, 189, 206).VEGF acts through two major tyrosine kinase receptors on endothelial cells, Flt-1 (VEGFR1) and KDR (VEGF R2).Besides VEGF another type of angiogenic factors is the Angiopoietin family.Ang-1 and Ang-2 belong to a novel family of endothelial growth factors that function as ligands for tyrosine kinase receptor, Tie-2.Tie-2 is known to be involved in angiogenic processes and is ubiquitously expressed on endothelial ceils throughout the vasculature.There is increasing evidence on the role of VEHG and its receptors in pathological and physiological angiogenesis within the reproductive tract.The aim of this presentation would be to give you a background of the initial studies which formed the link between VEGF and pathological and physiological angiogenesis within the reproductive tract.