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Enoxaparine-immobilized gelatin/poly (ε-caprolactone) or Eudragit(R) RLPO nanogels in presence of tetraethyl orthosilicate (TEOS) or triethyl phosphate as polycondensation reagents were designed and characterized for their sustained drug delivery ability.Enoxaparine(R) (Anti-Xa 1000 UI/mL) was used as a model drug at different concentrations (300, 500, 1000 and 2000 UI/mL).