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Objective Abundant nerve fibres and synapses netting to a neuron directly or indirectly are involved in the processing of the acoustic information.However they could be functionally simplified as a single "wire" (comprised of different media) and "joint" (connecting different media) to do transduction and transmission of the information, respectively.Although this, there is still no method to analyze the functional transduction and transmission efficacy of an activated pathway.The present study is to explore if there is a method to identify the functional transduction and transmission efficacy of an activated pathway.Methods In this study, the neuronal responses of mouse central nucleus of inferior colliculus (ICC) to pure tones varying in frequency and amplitude were reinvestigated by the feature of their latency (L)-amplitude (A) functions for different frequency tones using extracellular recording technique and a method to identify the functional transduction and transmission was developed.Results The L-A function for a given frequency acoustic stimulus (AS) yields asymptotic L (L0) and A (A0) independent of acoustic stimulus, and that the L-A functions for different frequencies of the AS could be superimposed irrespective of their L and A.The differences of the asymptotical L (ΔL) and A (ΔA) between two L-A functions represent the functional "fibre/ pathway" transduction and "synaptic" transmission efficacy.And ΔA and ΔL are different from frequencies of AS and neuons.Conclusion the results suggest that the synapses and fibres evoked by different frequency AS are different, and the neuronal pathways are diverse.