The role of18F-FDGuptakefeaturesinthedifferentialdiagnosisof solitarypulmonarylesionswi

• 作 者: MingZhao HongxingJin
• 机 构: The TumorHospitalofShanxiProvince
• 出 处: 中华放射学学术大会2016、中华医学会第23次全国放射学学术大会暨中华医学会第24次全国影像技术学术大会
• 发表日期: 2016年5期
• 关键词: Solitary pulmonary lesions 18F-FDG PET/CT

　　Objective: The aimofthisstudyistoevaluatethevalueof18F-FDGuptakefeaturesinthediagnosisofsolitarypulmonary lesions. Methods: Onehundredthirty-ninepatientswithsolitarypulmonarylesionsweredividedintofulluptake,circularuptake,multifocus uptake,milduptake,andno-uptakegroupsaccordingtotheuptakefeaturesof18F-FDGinsolitarypulmonarylesions.The incidenceofbenignandmalignantlesionsandthefalse-positiveandfalse-negativeratesineachgroupwereanalyzed.The sensitivity,specificity,accuracy,positivepredictivevalue(PPV),andnegativepredictivevalue(NPV)ofthemethodusing18F-FDG uptakefeaturescombinedwithmaximumstandarduptakevalue(SUVmax)(SUVmethod)inthedifferentialdiagnosisofsolitary pulmonarylesionswereevaluated. Results:Therewere89malignantand50benignlesions.(1)Themalignantincidenceofthefulluptakegroupwas84.0%(63/75), andthereweresignificantdifferenceswhencomparedwiththeothergroupsexceptthecircularuptakegroup(16/23)(allP= 0.0001).Thebenignincidenceofthemulti-focusandno-uptakegroupswas83.3%(10/12)and82.4%(14/17),respectively,and thereweresignificantdifferenceswhencomparedwiththefulluptakeandthecircularuptakegroups,respectively(allP<0.05). Thebenignincidenceofthemilduptakegroupwas58.3%(7/12),andtherewerenosignificantdifferenceswhencomparedwith theothersexceptthefulluptakegroup(allP>0.05).Nostatisticalsignificancewasfoundbetweeneithertwooftheno-uptake, milduptake,andmulti-focusuptakegroups(allP>0.05).(2)IncaseswithSUVmax≥2.5,thefalse-positiverateinthemultifocus uptakegroupwas83.3%(10/12),whichwassignificantlyhigherthaninthefulluptake(12/75)orcircularuptakegroup(7/23)(allP<0.05).IncaseswithSUVmax<2.5,thefalsenegativeratesinthemildandno-uptakegroupswere41.7and17.6%(P=0.218).(3)Thesensitivity,specificity,accuracy,PPV,andNPVofthemethodusing18F-FDGuptakefeaturescombinedwith SUVmaxandthesingleSUVmethodwere88.7%/91.0%,62.0%/42.0%,79.1%/73.4%,80.6%/73.6%,and75.6%/72.4%, respectively. Conclusions:Themethodusinguptakefeaturesof18F-FDGcombinedwithSUVmaxcanimprovethediagnosticspecificityand accuracyofsolitarypulmonarylesions.Themulti-focusuptakefeaturemaybeabenignsign,whichstillneedsmoreresearchesto confirm.