【摘 要】
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Purpose: To compare the efficacy and safety of two triamcinolone acetonide regimens for the treatment of pretibial myxedema.Methods: A preliminary trial was performed to determine the intralesional 2.
【机 构】
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Department of Dermatology, Department of pathology, Department of nuclear medicine.Nuclear Industry
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Purpose: To compare the efficacy and safety of two triamcinolone acetonide regimens for the treatment of pretibial myxedema.Methods: A preliminary trial was performed to determine the intralesional 2.6mg triamcinolone acetonide acetate injection per 1 cm3 edematous skin tissue effective for the therapy of pretibial myxedema.In a randomized controlled trial, eligibility, inclusion and exclusion criteria were defined.Each inclusion patient was confirmed and staged by histopathology and Alcian blue.Colored ultrasound determined the depth of lesions and their volume was calculated.Regimen 1 was triamcinolone acetonide 2.6mg/cm3 edematous tissue at once every 3 days and regimen 2 at once every 7 days, 7 injection times as a therapy period.The injection stopped when the lesions disappeared.The adverse events were recorded.Results: 108 eligible patients were randomized into regimen 1 and regimen 2 respectively.106 patients completed the study (52 patients in regimen 1 and 54 patients in regimen 2).There were no significant differences between two groups in age, sex, occupation, lesion type, lesion stage and duration of diseases (p>0.05).At week 3, the cure rate (38/52,73%) in regimen 1 was higher than one (16/38,29%) in regimen 2 (P<0.005).At week 7, the cure rate (51/52,98%) in regimen 1 was higher than one (43/54,79.6%)in regimen 2 (P<0.005).Each of the regimens has 4 cases with mild adverse events.In the 7-month follow-up, 7 cases in the regimens recurred.Conclusion: Intralesional triamcinolone acetonide acetate injection is effective and safe for the treatment of pretibial myxedema.
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