ER stress-mediated renal fibrosis is attenuated by chemical chaperon 4-phenylbutyrate in vitro and i

• 作 者: Chih-Kang Chiang Li-Ping Chen Shing-Hwa Liu
• 机 构: Institute of Toxicology, College of Medicine, National Taiwan University;Department of Integrated Di
• 出 处: 第八届海峡两岸毒理学研讨会
• 发表日期: 2015年5期
• 关键词: 4-phenylbutyrate endoplasmic reticulum stress unilateral ureteral obstruction ap

　　Renal tubule interstitial fibrosis is the common and final pathologic change of kidney in end-stage renal disease.Endoplasmic reticulum (ER) stress contributes to the pathophysiological mechanisms during the development of renal fibrosis.Here, we investigated the protective effect of chemical chaperon sodium 4-phenylbutyrate (4-PBA) on renal fibrosis in vivo and in vitro.In a rat unilateral ureteral obstruction (UUO) model, 4-PBA mimicked endogenous ER chaperonin the kidneys.4-PBA significantly attenuated UUO-increased renal GRP78, CHOP, ATF4, and phosphorylated JNK protein expressions and UUO-decreased renal splicing XBP 1 protein expression.