The present study aimed to observe the effect of rosuvastatin preconditioning on inflammatory cytokines-IL-1β and IL-6 release in vascular smooth muscle cells(VSMCs)after ischemia reperfusion.Thirty-s
The study aimed to observe the protective effects of astaxanthin(ATX)and its molecular mechanism in SH-SY5Y cells.The SH-SY5Y cells were pre-treated with ATX(5,10,20 and 40 μmol/L)for 24 h and were co
Using an alpha-synuclein(aSYN)rat model of Parkinsons disease(PD),we evaluated three regimens of trehalose administration to identify an efficacious dosing regimen that can be used to clinically evalu
Hypertension is the major risk factor for cardiovascular and renal diseases that affect more than 1.5 billion people world-wide in the next 10 years[1,2].
Brain edema plays an important role in cerebral ischemic pathogenesis and indicates a worse result of ischemic stroke.Glibenclamide has gained attention for its prominent anti-edema property,but up to
The narrow therapeutic window of warfarin makes itself the most common drug involved in drug/herb-drug interaction,which often causes safety concerns,primarily bleeding.
Ca2+-activated Cl- channels play a crucial role in various physiological processes.However,the role of TMEM16A in vascular endothelial dysfunction during hypertension is unclear.
The present study aimed to observe the interaction between Poly(ADP-ribose)polymerase 1(PARP1)and sirtuin 6 deacetylase(SIRT6)in cardiac remodeling.Both PARP1 and SIRT6 are important NAD+-dependent en