【摘 要】
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The discovery that the inclusions present in neurons in all chronic neurodegenerative diseases contained ubiquitylated proteins stimulated much research eff
【机 构】
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Molecular Cell Biology School of Biomedical Sciences University of Nottingham Medical School Queen'
论文部分内容阅读
The discovery that the inclusions present in neurons in all chronic neurodegenerative diseases contained ubiquitylated proteins stimulated much research effort to understand the role of the ubiquitin proteasome system (UPS) in the disorders.It is now clear that protein ubiquitylation plays key roles in both the major cellular protein catabolic systemsthe UPS and selective autophagy.
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