Thrombin and Sphingosine-1-Phosphate Alter Local Lamellipodia Dynamics to Modulate Endothelial Barri

来源 :微循环国际研讨会暨第十三届全国中西医结合微循环学术会议(International Conference for Mic | 被引量 : 0次 | 上传用户：jekiyi

【摘要】

：

Thrombin and sphingosine-l-phosphate (S 1P) increase and decrease endothelial permeability, respectively, by modulating activities of Rho-family GTPases that co

【作者】

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Jerome W.Breslin

【机构】

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MolecularPharmacologyandPhysiology,MorsaniCollegeofMedicine,UniversityofSouthFlorida

【出处】

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微循环国际研讨会暨第十三届全国中西医结合微循环学术会议(International Conference for Mic

【发表日期】

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2013年9期

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Thrombin and sphingosine-l-phosphate (S 1P) increase and decrease endothelial permeability, respectively, by modulating activities of Rho-family GTPases that control the actin cytoskeleton and integrity of intercellular junctions.Our recent finding that endothelial cells in tightly confluent monolayers frequently display local lamellipodia led us to test the hypothesis that these dynamic adhesive structures are important for control of endothelial barrier function.

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Thrombin and Sphingosine-1-Phosphate Alter Local Lamellipodia Dynamics to Modulate Endothelial Barri

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