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Nuclear magnetic resonance was first observed in bulk matter by Edward Purcells group at Harvard and Felix Blochs group at Stanford in 1946.Magnetic resonance imaging(MRI)was first proposed by Paul Lauterbur in 1972.Since then,MRI has revolutionized medicine and biology.With the ever increasing use of MRI in biomedical research and clinical applications,MRI is entering a new era of technology development and practical applications.This talk will give an overview of MRI,discussing some of the longstanding technical challenges and new opportunities in the context of the new advances in computational imaging.