Ubiquitin ligase Huwe1 modulates proNGF/p75NTR in monkey cerebral ischemia-reperfusion injury

• 作 者: LihuaYu[1]GuoqianHe[1]JiachuanDuan[2]HongboZheng[1]WenmingXu[3]LiHe[1]
• 机 构: Department of Neurology,West China Hospital of Sichuan University,Chengdu 610041,China
• 出 处: 中国脑血管病大会2014
• 发表日期: 2014年期

　　Ischemic neuronal cell apoptosis is a principal neuropathological feature of stroke.The p75 neurotrophin receptor (p75NTR) induce apoptosis associated with JNK-p53-BAX pathway,p53 is the substrate of the HECT domain-containing E3 ubiquitin ligase Huwe1.Recent studies suggest that the precursor form of NGF (proNGF) binds to p75NTR,and blockade of proNGF/p75NTR interaction is efficacious in limiting neuronal apoptosis.Studies on tumour and phylogeny,shows that Huwe1 highly expressed in CNS,plays a role in the regulation process of cell apoptosis and variety of injury types.Our aim is to examine whether Huwe1 modulates proNGF/p75NTR in cerebral ischemia-reperfusion injury.