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Field applications have shown that amine inhibitor agents have some degree of foaming ability,which can affect the performance of the drilling fluid.Common antifoaming agents are not very efficient in this system, so its application is limited.The study presented in this paper investigated the effect of the amine agent on the viscosity and density of the drilling fluid.The results showed that the agent affected the performance of the drilling fluid greatly, and the foam that formed could not be eliminated completely by increasing the circulation.Then, a series of screening experiments was conducted for six different antifoaming agents.The results showed that the Span80 agent was the best de-foaming candidate when added into the drilling fluid with the amine agent.Even when more than 5.0% of the amine agent was added, the volume of formed foam in situ remained small.This method was recommended for use in many wells in the Linpan block, and the results have shown that this method is very efficient and practical.No foaming problems have occurred during drilling with amine-based drilling fluids.