To achieve single cell mass spectrometry,our group has worked on fundamental theory for ion suppression,development of novel ambient ionization mass spectrometry and the application for living cell an
SWATH/DIA mass spectrometry enables generation of proteomics data sets at increasing pace,leading to a series of computational challenges,which are currently partially relieved by improving the comput
Sample preparation is a critical step to ensure the sensitivity,accuracy,precision and throughput of both qualitative and quantitative proteome analysis.Bottom-up proteomics typically employs multiste
measurement errors systematically and quantitatively using the natural properties of isotopic distributions.Then,we propose an algorithm for label-free absolute protein quantification,LFAQ,which can c
that pGlycoNovo is suitable for identification of N-glycopeptides from different species.We also showed that pGlycoNovo could be used to identify the modifications on the glycans in fission yeast samp