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Background There have been no studies evaluating the efficacy ad potential risks of stronger neo minophagen C (SNMC) in pregnant women with chronic hepatitis B CHB Material and methods A total of 36 pregnant women with CHB, but without severe complications,were randomized to intravenously receive SNMC or S-adenosyl-L-methionine (SAM) daily for 4 weeks or until birth.Normalization of serum alanine transaminase (ALT) and aspartate transaminase (AST) levels and changes in ALT and AST levels from baseline were determined.All neonates were regularly examined for up to one year.