Methotrexate-Conjugated Polymeric Micelles in the Folate Receptor-Rich Cancer Treatment and Safety E

• 作 者: YukunHuang[1]FengGao[1]XiaolingFang[2]YanzuoChen[3]
• 机 构: Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Sh
• 出 处: 纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会
• 发表日期: 2015年期

　　Due to its high structural similarity to folic acid (FA) and the high expression of folate receptor in most solid tumors, MTX not only serves as a cytotoxic agent but also a homing ligand.In this work, the therapeutic effect of methotrexate (MTX)-conjugated Pluronic-based polymeric mixed micelles (F127/P105-MTX) on the folate receptor over-expressing tumors treatment and safety evaluation were investigated.