Comparison of the prognostic value of arterial lactate concentration, plasma organophosphate concent

• 作 者: Liang Sun Guo-qiang Li Peng-bo Yan Xin Yu Guo-feng Li Lu-qing Wei
• 机 构: Department of Intensive Care Medicine and Respiratory,Affiliated Hospital of Logistic University of
• 出 处: 2016中国中毒救治首都论坛暨第八届全国中毒及危重症救治学术会议
• 发表日期: 2016年12期

　　Objective:Initial arterial lactate has been used as a prognostic marker in patients with acute paraquat poisoning.However, prognostic value of initial arterial lactate in organophosphate poisoned patients is unknow.The aim of this study was to assess the usefulness of initial arterial lactate, initial plasma organophosphate concentration and APACHE Ⅱ score, for predicting death with identified organophosphate poisoned.Methods:117 patients with proven organophosphate self-poisoning were retrospective studied.Initial arterial lactate concentration, initial plasma organophosphorus concentration and APACHE Ⅱ score of the patients were compared for predicting death by analyzing receiver operating characteristic (ROC) curves.Results:Our resultes shown that there was no statistically difference between APACHE Ⅱ score, arterial lactate and plasma organophosphate concentration in terms of area under ROC Curve in predicting death.For prediction, the best cut offpoint was 17 for APACHE Ⅱ, 3.40mmol/L for arterial lactate, and 1.20 mmol/L for plasma organophosphate concentration.Positive correlation was observed between arterial lactate and APACHE Ⅱ score (ρ=0.457), as well as between arterial lactate and the length of hospitalization in survivors(ρ=0.406).Conclusion:These data demonstrate that initial arterial lactate can provide useful information in predicting prognosis in organophosphate poisoning.However, whether it can be used as a prognostic marker still need to be confirmed by large sample data.