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This paper provides a brief historical perspective of how biochemistry became a distinct discipline, how it became intricately linked to molecular biology, and how together these sciences should be taught at the undergraduate level as upper-level courses (for juniors and seniors) when students have acquired background course preparations in organic chemistry, cell biology and molecular genetics.With adequate background preparation, these courses can be taught with quantitative rigor, with thermodynamic and kinetic considerations, and with strong emphasis on the structure-function relationship of biomolecules.With information explosion in the recent decades, it is not possible to teach every topic in the fields of biochemistry and molecular biology within the confine of two short collegesemesters.My goals of undergraduate biochemistry teaching increasingly have focused on teaching the basics well, building up a repertoire of fundamental concepts and principles from which the students can learn to think integratively,to apply their knowledge in problem solving, and to develop their confidence of becoming an independent thinker and learner.I use many complementary activities-hands-on laboratory exercises, oral presentation, research proposal, and comprehensive exam-to foster the attainment of these goals.The ultimate goal of an undergraduate biochemistry education is to equip the students well for future pursuits in graduate school, medical/veterinary/dental (professional) school education, high-school teaching, or employment in university research laboratories or pharmaceutical industries.