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The purpose of this randomized control trial was to determine whether choline in combination with several doses of caffeine, could facilitate short-term visual and verbal memory and attention in adult and middle aged human subjects with normal cognitive function.The effects of several doses of caffeine in combination with choline on short-term visual and verbal memory, blood pressure and heart rate were assessed in 125 healthy adult and middle-aged men and women using six standardized tests from the Wide Range Assessment of Memory and Learning, Second Edition (WRAML 2).