【摘 要】
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Objective Immune escape plays an important role in tumor progression.In the present study, the expression of B7-H1, B7-H4 and Foxp3 involved in immune escape in gastric carcinoma was investigated and
【机 构】
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Department of Oncology,The Third Affiliated Hospital of Soochow University,185 Juqian Street,Changzh
【出 处】
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2014第十届全国癌症康复与姑息医学大会
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Objective Immune escape plays an important role in tumor progression.In the present study, the expression of B7-H1, B7-H4 and Foxp3 involved in immune escape in gastric carcinoma was investigated and the corresponding clinical significance was evaluated.Methods Immunohistochemistry was used to detect the expression of B7-H1, B7-H4 and Foxp3 in 100 gastric cancer specimens, and 30 paracarcinoma tissues were used as the control.Results Both B7-H1 and B7-H4 showed high expression level in gastric cancer tissues (65.0% and 71.0%), and the expression of B7-H1 and B7-H4 were positively correlated with the depth of tumor invasion, lymph node metastasis and (American Joint Committee on Cancer) AJCC stage (P<0.05).The number of Foxp3+ Tregs was much higher in gastric cancer tissues than control tissues, which was positively correlated with lymph node metastasis (P<0.05).Similarly, a positive correlation between B7-H1 or B7-H4 expression and the number of Foxp3+ Tregs was observed.The median overall survival rate of patients with high expression of B7-H1, B7-H4 and Foxp3 was significantly poorer than the patients with low expression of these proteins (P<0.05).COX regression multivariate analysis confirmed that lymph node metastasis, AJCC stage, and B7-H1 and Foxp3 overexpression were independent prognostic factors.Conclusion B7-H1, B7-H4 and Foxp3 were overexpressed in gastric cancer tissues.B7-H1 and Foxp3 are the negative prognostic factors for patients with gastric cancer.
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