【摘 要】
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Type 2 diabetes increase the risk of development of cognitive dysfunction in the elderly, in the form of shortterm memory and executive function deficits.Genetic and dietinduced models of type 2 diabe
【机 构】
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National Drug Clinical Trial Institution,Xinqiao Hospital,Third Military Medical University,Chongqin
论文部分内容阅读
Type 2 diabetes increase the risk of development of cognitive dysfunction in the elderly, in the form of shortterm memory and executive function deficits.Genetic and dietinduced models of type 2 diabetes further support this link displaying deficits in working memory, learning, and memory performance.The risk factors for diabetic cognitive dysfunction include vascular disease, hypoglycemia, hyperlipidemia, adiposity, lifestyle factors,and genetic factors.Using neuronimage technologies, diabetic patients with cognitive dysfunction shows whole brain atrophy, gray matter atrophy, hippocampal atrophy, and amygdala atrophy, increased ventricular volume and white matter volume, brain infarcts, impaired network integrity, microstructural abnormality, reduced cerebral blood flow and amplitude of lowfrequency fluctuations.The pathogenesis mechanisms of type 2 diabetes with cognitive dysfunction involve hyperglycemia, macrovascular and microvascular diseases, insulin resistance, inflammation, apoptosis, impaired neurogenesis, impaired bloodbrain barrier, and disorder neurotransmitters.Some antidiabetic drugs and Traditional Chinese Medicine partly improve diabetic cognitive dysfunction, but more clinical investigations are demanded to verify their efficiencies and novel drugs are urgent need to develop.Large clinical studies will provide further evidences of risks factors and biomarkers for diabetic cognitive dysfunction.Both novel disease animal models and advanced neuronimage technologies will help to investigate the exact pathogenesis mechanisms and to develop better therapeutic interventions and treatment.
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