Human NAD-dependent isocitrate dehydrogenase,existing as the α2βγ heterotetramer,catalyzes the decarboxylation of isocitrate into a-ketoglutarate in the Krebs cycle,which can be allosterically regulat
Gastrointestinal stromal tumor(GIST)is the most common malignant tumor of gastrointestinal tract.Mutated and activated Oncogene KIT and PDGFRA mutation and abnormal activation are the main factors for
Liver cancer is one of the most common malignancies with high recurrence rate.Besides radiotherapy and surgery,chemotherapy also plays an important role in the treatment of liver cancer.
Antibacterial autophagy(xenophagy)is an important host defense,but how it is initiated is unclear.Here we performed a bacterial transposon screen and identified a T3SS effector SopF that potently bloc