【摘 要】
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Background: Prostate Cancer (PCa) is one of the most common cancers in men.Many microbes were reported to be potential cause of PCa in the past 60 years, li
【机 构】
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基础医学研究所,军事医学科学院,北京,100850
【出 处】
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第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
论文部分内容阅读
Background: Prostate Cancer (PCa) is one of the most common cancers in men.Many microbes were reported to be potential cause of PCa in the past 60 years, like human papillomavirus (HPV), human cytomegalovirus (HCMV), herpes simplex virus (HSV), Epstein-Barr virus (EBV), BK virus (BKV), and xenotropic murine leukemia virus-related virus (XMRV).However, conflicting and controversial results were also reported and to date no microbe is accepted as an etiologic agent to PCa.Next Generation Sequencing (NGS) is more sensitive in detecting sequences in samples and RNA-seq can detect active microbes.We therefore attempted to analyze viral and bacterial sequences from RNA-seq data of PCa and benign prostate tissues, to inspect the potential association between PCa and microbes.
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