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  5. LncRNA HOTTIP mediated DKK1 downregulation confers metastasis and invasion in colorectal cancer cell

LncRNA HOTTIP mediated DKK1 downregulation confers metastasis and invasion in colorectal cancer cell

来源 :第19次全国干扰素与细胞因子学术会议 | 被引量 : 0次 | 上传用户：FishGWDC
【摘 要】
：
Background: Recent studies highlight long non-coding RNAs (lncRNAs) as key regulators of cancer biology that contribute to carcinogenesis.The lncRNA HOXA transcript at the distal tip (HOTTIP) is invol
【作 者】
：
Yifan Lian Jie Ding Zhonghua Ma Zhaoxia Wang Juan Li Yetao Xu Keming Wang 
【机 构】
：
Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing,210000
【出 处】
：
第19次全国干扰素与细胞因子学术会议
【发表日期】
：
2016年10期
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　　Background: Recent studies highlight long non-coding RNAs (lncRNAs) as key regulators of cancer biology that contribute to carcinogenesis.The lncRNA HOXA transcript at the distal tip (HOTTIP) is involved in the development of several cancers.Our previous study demonstrated that HOTTIP could promote colorectal cancer (CRC) cell proliferation via silencing of p21 expression.However,the potential role of HOTTIP in CRC metastasis has not yet been discussed.
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