【摘 要】
：
The vexatious difficulty in delineating percutaneous ablation margins of tumors in time represents a prominent obstacle toward better outcome of minimally invasive thermal ablation.To date, the ablati
【机 构】
：
Chongqing Key Laboratory of Ultrasound Molecular Imaging,Institute of Ultrasound Imaging,The Second
【出 处】
：
第三届全国暨国际超声分子影像及生物效应和治疗学术会议
论文部分内容阅读
The vexatious difficulty in delineating percutaneous ablation margins of tumors in time represents a prominent obstacle toward better outcome of minimally invasive thermal ablation.To date, the ablative tumors images are often limited by inadequate spatial resolution and contrast in modern real-time imaging methods.Here we show a specifically exquisite "small-to-big" nanodroplet,which can help intra-operatively delineate the thermal ablation margins in real-time both in vitro and in vivo via a novel phase-transition strategy called microwave induced droplet vaporization (MWDV).Simultaneously,this nanodroplet,as a synergistic agent,can also significantly augment the efficiency of percutaneous ultrasound (US)-guided microwave ablation (MWA) both ex vivo and in vivo via a combinatorial strategy with US.This effect can make a contribution to solve other critical issues,such as incomplete ablation, in modern minimally invasive thermal ablation.Therefore, the successfully exquisite "small-to-big" nanodroplet provides an excellent platform for percutaneous US-guided MWA to enable more accurate ablation margin imaging and synergistic MWA efficiency of tumors.
其他文献
Objective To develop an safety,injectable and biodegradable material using calcium phosphate cement containing Fe3O4 nanoparticles for minimally invasive magnetic hyperthermia ablation of tumor.Method
Background To study the efficacy of intravenous MSCs transplantation under diagnostic ultrasound (US) irradiated SDF-1-loaded Microbubbles (MBs) on the improvement of MSCs homing and cardiac function
Objective To investigate the utility of fusion imaging of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CT)/magnetic resonance imaging (MRI) before radiofrequency abla
Objective To investigate the transfection efficiency of combining ultrasound targeted microbubble destruction (UTMD) and classic nuclear localization signal (cNLS) peptide for facilitating targeted ge
Objective The separation of tumor diagnosis and treatment is one of major issues in the clinic.Use of activatable theranostics for the combination of diagnosis and treatment of cancer can provide the
Objective The aims of this study were to develop targeted cationic microbubbles conjugated with a CD 105 antibody (CMB 105) for use in targeted vascular endothelial cell gene therapy and ultrasound im
Objective To investigate a novel and self-made perfluorohexane-encapsulated hollow mesoporous prussian blue nanoparticles (HMPBs) can enhance the therapy efficiency of tumor ablation by high-intensity
Objective To compare the efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) and radiofrequency ablation (RFA) for treatment of benign thyroid nodules (BTNs).Materials and M
Objective To prepare a pH-sensitive dual-targeted doxorubicin-loaded nanoparticle and evaluate its antitumor activity in vitro.Methods The folatc and cRGD were conjugated to the nanoparticle using hep
Objetctive Toprepareintracellular adhesion molecule 1 (ICAM-1) targeted microbubbles and fulfill molecular imaging of IRI inflammation with contrast-enhanced ultrasound (CEUS).Moreover a more precise