【摘 要】
：
Beclin 1 was the first autophagic gene identified in mammarlian cells with roles in mediating autophagy and apoptosis.Earlier studies showed that beclin 1 expression was down-regulated with mono-allel
【机 构】
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School of Medicine Tsinghua University China
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Beclin 1 was the first autophagic gene identified in mammarlian cells with roles in mediating autophagy and apoptosis.Earlier studies showed that beclin 1 expression was down-regulated with mono-allelic deletions in human breast cancer cells and the decreased expression ofbeclin 1 could contribute to tumorigenesis.But the status of its expression and regulatory mechanisms in other cancers were remained to be determined.We detected the expression status of beclin 1 in the tumor tissues and corresponding adjacent normal tissues from 60 pairs of breast, gastric and colorectal tumors.We found that beclin 1 expression was associated with breast and gastric cancers, in which 19 samples were obtained with significantly decreased expression ofbeclin 1.Association between beclin 1 mRNA expression and clinocopathologic parameters was found in none of the three different kinds of cancer.
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