【摘 要】
：
Sphin gomyelin synthase (SMS) plays an important role in plasma atherogenic lipoprotein metabolism, inflammation, and the development of atherosclerosis.To understand whether the impaired apoB secreti
【机 构】
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School of Pharmacy Fudan University School of Pha
【出 处】
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2014年第十二届全国脂质与脂蛋白学术会议
论文部分内容阅读
Sphin gomyelin synthase (SMS) plays an important role in plasma atherogenic lipoprotein metabolism, inflammation, and the development of atherosclerosis.To understand whether the impaired apoB secretion and inflammation response is a direct result from lack of SMS activity, in this study, we prepared a series of compounds that inhibit SMS activity.Further, we characterized Dy105, the most potent inhibitor.We found that Dyl05 treatment significantly reduces SM levels in SM-rich microdomain on cell membranes.
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