Influence of olfactory bulb removal on neurogenesis in the subventrcular zone and rostral migratory

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户：uj_mosquito11

【摘要】

：

It has been demonstrated that the olfactory bulb (OB) is the sole target for neuroblasts originated from the subventricular zone (SVZ).In order to explore the effects of the OB on the neurogenesis in

【作者】

：

Yan MENG Dian-Shuai GAO Bing-Fang LIU Qing CAI Qun-Yuan XU

【机构】

：

Beijing Research Laboratory for Brain Aging, Xuan Wu Hospital, Capital University of Medical Science

【出处】

：

中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the

【发表日期】

：

2007年12期

【关键词】

：

Olfactory Bulb Removal Neurogenesis SVZ RMS

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　　It has been demonstrated that the olfactory bulb (OB) is the sole target for neuroblasts originated from the subventricular zone (SVZ).In order to explore the effects of the OB on the neurogenesis in the SVZ and rostral migratory stream (RMS) in adult mammals,a surgical removal of the OB was performed in the rat.The Nissl staining and immunohistochemistry for showing glial fibrillary acidic protein (GFAP),bromodeoxyuridine (BrdU),and polysialylated neural cell adhesion molecule (PSA-NCAM) were done in the brain tissue from adult SD rats in different survival times after removal of the OB and in the sham group.The sections were observed under light-microscopy,and the Leica DM LA image analysis system Qwin software and SPSS statistic analysis software were used to estimate the cell number and area.In addition,the ultrastructural characteristics of the cells in the SVZ and RMS were observed under electro-microscopy.

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Influence of olfactory bulb removal on neurogenesis in the subventrcular zone and rostral migratory

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