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目的:探讨脂联素与子痫前期的关系。方法:抽取25例子痫前期患者为子痫前期组(轻度11例,重度14例);15例妊娠期高血压疾病患者为妊娠期高血压疾病;分别取不同孕龄的45例正常孕妇,分为早孕组、中孕组及晚孕组各15例;另取正常育龄非妊娠妇女15例为对照组;空腹抽肘取静脉血,用ELISA法测定血清脂联素浓度。结果:子痫前期组血清脂联素浓度为(9.90±2.17)mg/L,显著低于妊娠期高血压疾病组〔(14.85±3.45)mg/L〕(P<0.05);子痫前期组中重度子痫前期患者的血清脂联素浓度〔(8.50±2.12)mg/L〕,明显低于轻度子痫前期患者〔(10.32±3.96)mg/L〕(P<0.05);子痫前期组的血清脂联素浓度明显低于孕晚期组〔(15.52±3.01)mg/L〕(P<0.05);亦明显低于对照组〔(16.72±2.00)mg/L〕(P<0.05)。妊娠期高血压疾病组血清脂联素浓度与孕晚期组和对照组相比,无显著差异(P>0.05)。孕晚期组与对照组比较,差异无统计学意义(P>0.05);正常妊娠不同孕龄组之间的血清脂联素浓度相比,差异无统计学意义(P>0.05)。结论:血清脂联素浓度与子痫前期的发展及病情严重程度呈负相关,脂联素可能促进了该病的发生发展。
Objective: To investigate the relationship between adiponectin and preeclampsia. Methods: Twenty-five preeclampsia patients were selected as preeclampsia group (mild 11 cases, severe 14 cases). 15 cases of hypertensive disorder complicating pregnancy were gestational hypertension. 45 normal pregnant women of different gestational age were selected, Divided into early pregnancy group, the second trimester group and the late pregnancy group of 15 cases; another non-pregnant women of normal childbearing age 15 as control group; fasting elbow to take venous blood, serum concentrations of adiponectin by ELISA. Results: Serum adiponectin concentration in preeclampsia group was (9.90 ± 2.17) mg / L, which was significantly lower than that in gestational hypertension group (14.85 ± 3.45 mg / L) (P <0.05) Serum levels of adiponectin in patients with moderate-severe preeclampsia were significantly lower than those in patients with mild preeclampsia [(8.50 ± 2.12) mg / L 〔〕 (10.32 ± 3.96) mg / L〕 (P <0.05; The level of serum adiponectin in the pre-treatment group was significantly lower than that in the third trimester [(15.52 ± 3.01) mg / L〕 (P <0.05) and also significantly lower than that in the control group [(16.72 ± 2.00) mg / L〕 ). Serum adiponectin concentrations in gestational hypertension group were not significantly different from those in the third trimester and the control group (P> 0.05). Compared with the control group, there was no significant difference in the third trimester of pregnancy (P> 0.05). There was no significant difference in serum adiponectin concentrations between normal pregnant women of different gestational age groups (P> 0.05). Conclusion: Serum adiponectin concentration is negatively correlated with the development of preeclampsia and severity of illness. Adiponectin may promote the occurrence and development of the disease.