【摘 要】
：
Nocardia is resistant to many antibiotics,which are beta-lactams,aminoglycosides,macrolides and rifampicin (RIF).The complete genome sequence analysis of N.farcinica IFM 10152 has revealed the existen
【机 构】
：
Department of Bioactive Molecules,National Institute of Infectious Diseages,Shinjuku,Tokyo162-8640,J
【出 处】
：
15th International Symposiium on the Biology of Actinomycete
论文部分内容阅读
Nocardia is resistant to many antibiotics,which are beta-lactams,aminoglycosides,macrolides and rifampicin (RIF).The complete genome sequence analysis of N.farcinica IFM 10152 has revealed the existence of various drug resistance mechanisms,for example transporters,drug modification enzymes,drug target alterations and so on [1].As for RIF.rpoB2 gene,which is the duplicated RNA polymerase beta-subunit gene,has experimentally been demonstrated as a resistance determinant [2].
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