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我们曾观察到腐植酸可以促进大鼠慢性实验性胃溃疡的愈合,并可以直接作用到壁细胞抑制胃酸分泌,但不能直接作用到G细胞抑制胃泌素的释放。这些作用和前列腺素(PG)的作用相似。这使我们想到,腐植酸是否具有与PG类似的其他作用?本实验选用消炎痛——一种PG合成和释放的有效抑制剂——造成大鼠胃粘膜损伤的模型,观察腐植酸的抗溃疡作用是否也象PG那样与细胞保护作用有关。
We have observed that humic acid can promote the healing of chronic experimental gastric ulcers in rats, and can directly act on the parietal cells to inhibit gastric acid secretion, but it cannot directly affect the G cells to inhibit gastrin release. These effects are similar to those of prostaglandins (PG). This reminds us whether humic acid has other effects similar to those of PG. In this study, indomethacin, an effective inhibitor of PG synthesis and release, was used to model the gastric mucosal damage in rats and observe the anti-ulcer effects of humic acid. Whether the effect is also related to cytoprotection like PG.