UGT1A1*6,UGT1A7*3 and UGT1A9*1b Polymorphismsare predictive markers forsevere toxicity in Chinese me

来源 :The 4th International Conference of Genomics Beyond Biologic | 被引量 : 0次 | 上传用户:sisi_g
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  Irinotecan-induced severeneutropenia and diarrhea which are still unpredictable hasrestrained the dose and clinical efficiency of itself.A total of 70 Irinotecan-treated patients with histologically confirmed metastatic gastrointestinal cancer were included in ourstudy.Despite of genotyping hot-reported alleles identified abroad,we specifically adopteddirect sequencing to avoid the ethnic heterogeneity and to identifynovel variations.We sequenced the promoter(-1000bp)and exon 1 regions of UGT1A1,UGT1A7 and UGT1A9,and performed comprehensive analysis of their genetic polymorphisms to determine the correlation between inherited genetic variations and toxicity Irinotecan-induced.
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