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Various in silico models for describing gastrointestinal absorption and/or disposition of drugs following oral or intravenous administration are available for drug development purposes and are now widely used by pharmaceutical companies.Such models are lacking for sublingual drug delivery and is generally not available.The purpose of the present presentation is to demonstrate the utility of such an in silico model for assessing sublingual drug delivery using propranolol sublingual formulation as an example..Propranolol plasma concentrations (PPC) in haman subjects after administration of 10mg propranolol HCl sublingually followed by swallowing of the saliva containing the dissolved drug was evaluated.A special Advanced Compartmental Absorption and Transit(ACAT) model that incorporates muscosal transit to the existing GastroPlus program was used.This model not only allows simulation of the PPC but also calculates per cent absorbed via the oral cavity and gut,in addition to liver metabolism.Using initial estimated values based on physiologic consideration in combination with a newly generated mucosal transit time,excellent fit of PPC was obtained and detail results will be demonstrated This model may prove to be useful for evaluation and optimization of other sublingual drug development in the future..