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Epoxyeicosatrienoic acids (EETs), the eicosanoids derived from arachidonic acid (AA) via the cytochrome P450 epoxygenase pathway, possess vasodilation, anti-inflammation, and they are broken down into latent diols by soluble epoxide hydrolase (sEH), and so induction or inhibition of this enzyme would be expected to enhance the beneficial properties of EETs.