Correlative analysis of metabolite profiling of icarian in rat Plasma by rapid resolution LC-TOF/MS

• 作 者: QianQian;ESun;XiaobinTan;LiCui;JinXin;XiaobinJIA;
• 机 构: Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of
• 出 处: 第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
• 发表日期: 2011年期

　　The AB SCIEX TripleTOFTM 5600 System is an innovative breakthrough in LC/MS/MS performance that uniquely integrates comprehensive qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform.In this work, the metabolite profiles of icarian in rat plasma were qualitatively described, and the possible metabolic pathways of icarian were subsequently proposed.After oral administration of icarian, plasma samples were collected and pretreated by protein precipitation.