Losartan increases tumor permeability to promote drug distribution and antitumor efficacy of pH sens

• 作 者: LiZhang;YangWang;YutingYang;HuileGao;QinHe;
• 机 构: Key Laboratory of Drug Targeting and Drug Delivery Systems,West China School of Pharmacy,Sichuan Uni
• 出 处: 2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2014年期

　　The failure of sufficient accumulation of nanoparticles in tumor tissues is a primary problem to tumor therapy, which was because the extracellular matrix (ECM) produced by tumor and stromal cells and the poor tumor-target ability of nanoparticles.The ECM, containing collagen, hyaluronan and proteoglycans, can compress the tumor vessels and leads to impaired drug delivery.