Aging exaggerated proliferation of vascular smooth muscle cells is related to attenuation of Jagged1

• 作 者: xiaojingWu[1]LanHuang[1]YunzengZou[2]JunboGe[2]
• 机 构: The Cardiovascular Center of Xinqiao Hospital,Third Military Medical University,Chongqing 400037,Chi
• 出 处: 第17届全军心血管内科学术会议
• 发表日期: 2011年期

　　Objective: Aging has been shown to enhance the neointimal formation due to abnormal growth of vascular smooth muscular cells (VSMC), which is regulated by endothelial functions.The mechanism of how endothelium affects the growth of VSMC in the process remains unclear.We here examined the role of Jagged1, a regulator for cell growth.