论文部分内容阅读
Stem cell-like cancer cells, a minor population in tumour mass acting as the source of tumour recurrence and metastasis, are extraordinarily resistant to chemotherapeutic drugs, leading to a major clinical challenge.Developing novel approaches to reverse this formidable drug resistance may significantly improve clinical outcomes of cancer patients.Here we show an innovative approach by tumour cell-derived microparticles (T-MPs) packaging drugs to reverse tumour-repopulating cancer cell (TRC) drug resistance.We show that TRCs preferably take up T-MPs by exploiting their physical softness and deformability;the entered T-MPs release drugs that effectively killed TRCs.The underlying mechanisms involve T-MPs interfering with drug efflux and promoting drug nuclear entry.