p12-LOX promotes skin carcinogenesis via up-regulating of Ezrin expression

• 作 者: Jingchun Jin Huixin Lv Yunjie Hui Yue Ma Zhenhua Lin Yingshi Piao
• 机 构: Cancer Research Center, Yanbian University Medical College, Yanji 133002 , China;Department of Hemat
• 出 处: 第二届全国抗衰老医学大会暨首届中国干细胞与抗衰老美容高峰论坛
• 发表日期: 2012年12期
• 关键词: p12-LOX Ezrin soft agar colony formation cloning efficiency target

　　Accumulating evidence suggests that platelet-type 12-1ipoxygenase (pl2-LOX) and Ezrin play an important role in tumor development.However,how p12-LOX and Ezrin contribute to the skin carcinogenesis is still not well understood yet.This study is aimed to investigate the roles and mechanism of pl2-LOX and Ezrin in skin carcinogenesis,and to provide the effective target of chemoprevention for skin carcinogenesis.The mRNA expression of p12-LOX and Ezrin were significantly higher in B16 cell,followed by initiated JB6 P+ cell,then the normal JB6 P-cell,and its expression was further increased in JB6 P+ cells by tumor necrosis factor (TNF)-□.