论文部分内容阅读
目的：通过全基因组重测序对抑郁症的相关基因进行挖掘,验证之前报道过的与抑郁症相关基因(5-HTTLPR,HTR1A,HTR2A,TPH1and BDNF)以及找到一些特异性基因。方法：采集临床诊断的抑郁症患者和正常同性别亲本对照地外周血,构建高通量文库,进行基因组重测序以及生物信息学分析。
全基因组重测序初探抑郁症发病机制
【摘 要】
：
目的：通过全基因组重测序对抑郁症的相关基因进行挖掘,验证之前报道过的与抑郁症相关基因(5-HTTLPR,HTR1A,HTR2A,TPH1and BDNF)以及找到一些特异性基因。方法：采集临床诊断
【机 构】
：
北京市理化分析测试中心,北京,100089;北京市基因测序与功能分析工程技术研究中心首都医科大学附属北京友谊医院中医科
【出 处】
：
第二届全国计算生物学与生物信息学学术会议
【发表日期】
：
2015年4期
其他文献
As one of the most important kinds of hormones,abscisic acid(ABA)regulates crucial physiologically developmental processes and water stress responses by its
会议
Primer SpannerA Web-based Platform to Design PCR Primers for High Efficient Site-directed Mutagenesi
Background: PCR-based strategy has economical and efficient application in site-directed mutagenesis(SDM)and DNA assembling such as PCR-based vector constru
Negatively charged residues at the external mouth of Kir2.2 channel concentrate K+ ions to relieve e
Background: Kir channels display voltage-dependent block by cytosolic cations such as Mg2+and polyamines that causes inward rectification.
香蕉束顶病毒(Banana bunchy top virus,BBTV)是矮缩病毒科(Nanoviridae)香蕉束顶病毒属(Babuvirus)的代表种,其基因组至少由6个大小约1 kb的环形单链DNA分子组成。
会议
高通量的转录组测序(RNA-seq)在模式和非模式物种的研究中已开始得到广泛应用。然而，在没有参考基因组序列的情况下，将海量的转录组短序列组装成正确的基因集面临很大困难
Background:Expression of a protein coding gene is subjected to multiple layers of regulations,among which translational regulation has been increasingly rec
香蕉束顶病毒(Banana bunchy top virus,BBTV)是矮缩病毒科(Nanaviridae)香蕉束顶病毒属(Babuvirus)的多组分单链DNA病毒,至少含有6个大小约1.1 kb的环状ssDNA.除DNA2外,
会议
Background:As a crucial step in drug discovery,identifying protein targets for novel drug candidates has been gaining much concerns.However,testing drug can
Fractionation of cornstalk by alkali-catalyzed organosolv pretreatment to monosaccharides and high-v
Fractionation of cornstalk into carbohydrate(cellulose and hemicellulose)and lignin,was carried out using alkali-catalyzed organosolv pretreatment(ACOS).The
Immobilization of 5-adenylic deaminase onto towel cellulose modified by p-β-sulfate ethyl sulfone an
5-Adenylic deaminase(5-AD)from Aspergillus melleus was immobilized on cotton towels modified by p-β-sulfate ethyl sulfone aniline(SESA)and its functional p