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现代生命科学种种发现告诉人们:生命活动均以分子事件为其结构、能量或信息基础。无论是生物化学的循环级联反应与酶的高选择催化特性,遗传信息的传递、表达与调控,还是细胞增殖、分化与衰老,免疫中的信号、物质传递与调控,均离不开生物分子间的相互作用。例如,药物作为一类重要的生物活性物质与血浆蛋白(如白蛋白、α_1-酸性糖蛋白)存在可逆的结合平衡。血液中只有游离药物可透过血管到达活性位点,产生药效和引发副作用。
The discovery of modern life sciences tells people: life events are based on molecular events as their structure, energy or information base. Both biochemical cycle cascade reaction and the enzyme’s high selective catalytic properties, the transmission of genetic information, expression and regulation, or cell proliferation, differentiation and aging, immune signals, substance transfer and regulation are inseparable from the biological molecules Interaction between. For example, drugs as a class of important bioactive substances have a reversible binding equilibrium with plasma proteins such as albumin, alpha-1-acid glycoprotein. Only free drugs in the blood can reach the active site through the blood vessels, resulting in efficacy and triggering side effects.