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目的:血管加压素(AVP)对严重创伤/休克所导致的血管低反应性和血管平滑肌细胞(VSMC)钙敏感性降低有明显的恢复作用,但具体机制尚未完全阐明。PKC-ε亚型作为PKC家族新型亚家族成员,是非钙依赖对佛波酯或二脂酰甘油敏感的Ser/Thr蛋白激酶,在多种组织和细胞中均有表达。有报道PKC
OBJECTIVE: Vasopressin (AVP) has a significant regressive effect on the vascular hyporesponsiveness induced by severe trauma / shock and the decreased calcium sensitivity of vascular smooth muscle cells (VSMCs), but the exact mechanism has not been fully elucidated. As a new subfamily member of PKC family, PKC-ε subtype is a non-calcium-dependent Ser / Thr protein kinase sensitive to phorbol ester or diacetylglycerol, which is expressed in various tissues and cells. There are reports of PKC