Collagen Type Ⅱ Hydrogel-Encapsulated Bone Marrow-derived MSCs versus Bone Marrow Nucleated Cells in

• 作 者: YiZhang[1]XiaobinTian[1]FuyouWang[2]JiarongChen[2]ZhigangNing[2]LiSun[1]LiuYang[2]
• 机 构: Department of Orthopaedic Surgery,Guizhou Provincial People's Hospital GuiYang,550002,China
• 出 处: 海峡两岸骨科专委会学术交流会、抗震救灾五周年学术研讨会暨第十届华西国际骨科论坛
• 发表日期: 2013年期

　　Although experiments have confirmed that mesenchymal stem cells (MSCs) are the most promising seed cells in the treatment for cartilage defects, the separation and purification of MSCs remain complex and uncertain.Bone marrow nucleated cells may be another option.But whether it is effective enough to substitute MSCs? In this study, twenty Guizhou minipigs were used to create full-thickness chondral defects of 6.0 mm in diameter in the knee joints, and divided between two time points (4 and 8 weeks) for final assessment.