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  5. Multiple copies of a linear donor fragment released in situ from avector improve the efficiency of z

Multiple copies of a linear donor fragment released in situ from avector improve the efficiency of z

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：gongzi8886
【摘 要】
：
Homologous recombination (HR) is a strategy for genetic correction.The efficiency of HRcan be increased by creating a targeted double-strand break (DSB) via zinc-finger nucleases(ZFNs) and/or by intro
【作 者】
：
Weifeng Zhang Dan Xiao Dongyang Wang Xiaojing Zheng Haibin Xia 
【机 构】
：
Shaanxi Normal University
【出 处】
：
中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议
【发表日期】
：
2014年3期
【关键词】
：
zinc-finger nuclease homologous recombination adenoviral vector site-specifici n 
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Homologous recombination (HR) is a strategy for genetic correction.The efficiency of HRcan be increased by creating a targeted double-strand break (DSB) via zinc-finger nucleases(ZFNs) and/or by introducing linear donor DNA intracellularly.
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