Wentilactone B from Aspergillus wentii induces cell cycle arrest and apoptosis in hepatoma SMMC-7721

• 作 者: Lei Miao Caiguo Huang
• 机 构: Second Military Medical University, Xianghyin Road No.800,Yangpu, Shanghai
• 出 处: 14th international symposium on viral hepatitis and liver di
• 发表日期: 2012年8期

Background: Hepatocellular carcinoma (HCC) is one of the least curable malignancies worldwide.Developing new therapeutic and preventive strategies could be effective in the prognosis and treatment of HCC.Wentilactone B (EN-48-57) is one of the six derivatives separated from Aspergillus wentii (EN-48),and it has been proved that Wentilactone B exerted a more significant antibacterial and cytotoxic activity in several tumor cell lines,especially in human hepatoma cell line (SMMC-7721).