Because of its unique physicochemical properties and excellent biocompatibility,polydopamine(PDA)has been utilized as a novel platform for biosensing and bioimaging.
Cyanobactins are a group of post-translationally modified ribosomal peptides of which the patellamides are the most complex examples.
Maintaining proteostasis is an essential housekeeping function for cell survival.It involves chaperones and degradative pathways to ensure proteins fold correctly and to remove those that are misfolde
Gold nanoparticles(AuNPs)as potent theranostic agents have extensively been studied for photothermal therapy,radiosensitization,and photoacoustic(PA)imaging of cancers.
Increasing knowledge on the understanding interactions of aptamer with misfolded proteins(including monomer,oligomer and amyloid fibril)is crucial for diagnosis of amyloid diseases.
蛋白质作为基因表达产物是生命活动的执行者，其生理功能往往取决于它的分子构象，因此研究蛋白质构象转变具有重要意义.目前许多光物理学手段已用于研究各种物理、化学和环境因素及药物分子对蛋白质构象的影响[1].BSA 是一种生物体内含有两个色氨酸残基(Trp)的无辅助因子运载蛋白，常被用作模型蛋白、分散剂及合成功能材料的模板[2].
以DNA 为基础的自组装技术已经可以制备有着复杂几何构型的纳米结构。由于DNA 纳米结构的结构可设计、可寻址修饰的特性,多种功能基团可以被准确的定位在DNA 模板之上,从而得到可调控的各种性能。我们的实验显示,DNA 纳米结构可以精确的定位组装金属纳米粒子或者纳米棒形成三维结构,来获得可调控的等离子体光学手性信号。
Fluorescence-based techniques are promising analytical tools in tracking protein localizationand in facilitating the investigation on protein functions(1).
Sialylconjugates on cell surfaces are involved in many biological events such as cellular recognition,signal transduction,and immune response.It has been reported that aberrant sialylation at the non-
群体感应(quorum sensing,QS)是微生物通过分泌、释放一种被称为自体诱导剂(AI-2)的信号分子,并感知其浓度变化,来检测菌群密度、调控菌群生理功能,从而适应周围环境的一种信号交流机制。当信号分子的浓度达到一定阈值时,进入细菌内部,调控某些特定基因的表达,发生如共生现象、生物发光、孢子形成、毒性基因的表达、Ti质粒的接合转移、色素产生、生物膜的形成和细菌群体移动性等生物现象,这其中很