【摘 要】
:
Objective Insulin resistance and β-cell function are different between the young and elderly diabetes individuals, which are not well elaborated in the non-diabetic ones.We compared insulin resistance
【机 构】
:
Fujian Provincial Hospital
【出 处】
:
中华医学会第十四次全国内分泌学学术会议
论文部分内容阅读
Objective Insulin resistance and β-cell function are different between the young and elderly diabetes individuals, which are not well elaborated in the non-diabetic ones.We compared insulin resistance and β-cell function between young and old adults from normal glucose tolerance (NGT) to pre-diabetes which was subdivided into isolated impaired fasting glucose(i-IFG), isolated impaired glucose tolerance(i-IGT),or a combination of both (IFG/IGT).
其他文献
目的 明确miR-17~92在胰岛β细胞功能调控中的作用以及机理方法 1)通过Cre-loxp系统构建胰岛β细胞特异性敲除miR-17~92基因的基因工程鼠;常规监测小鼠代谢相关指标;测量基因敲除鼠在体和离体的胰岛素分泌情况;观察胰腺的组织形态学并定量计算β细胞数量、体积、质量,胰岛β细胞的凋亡、增殖能力;荧光定量RT-PCR检测胰岛细胞胰岛素合成分泌相关基因表达情况.Western实验检测PTE
目的:评估利格列汀在2型糖尿病合并冠状动脉疾病患者中的安全性和疗效方法:2型糖尿病(T2D)患者的冠心病(CAD)的发病率和死亡率升高.我们纳入一些随机、安慰剂(PBO)对照研究数据,对DPP-4抑制剂利格列汀(LINA)5 mg治疗CAD患者的患者安全性和疗效数据(采用SMQ查询"栓塞和血栓事件"定义)进行了考察.安全性分析集包括治疗持续时间≥12周的患者(19项试验;LINA,n=451;PB
目的 全基因组关联分析发现KLF14基因与2型糖尿病密切相关.然而KLF14与糖代谢和胰岛素信号通路的关系尚不明确,本文旨在阐明其相互作用关系.方法 基因mRNA和蛋白表达分别用Q-PCR和western blot检测;2-脱氧葡萄糖法测定糖摄取;利用western blot法测定胰岛素信号通路水平变化.
目的 了解重庆某社区人群十年来糖尿病及糖尿病前期患病率的变化趋势.方法 调查分别于2003年、2008年及2013年在重庆市沙坪坝区某社区进行,包括人体学测量、空腹血糖检验和口服75g无水葡萄糖耐量试验(oral glucose tolerance test,OGTT).糖尿病及糖尿病前期根据世界卫生组织(World Health Organization,WHO)1 999年诊断标准诊断.被调查
目的 在前期研究基础上,探讨可导致迟发DM的突变前胰岛素原R6C和R6H的无效转位导致β细胞衰竭和DM的分子机制方法 1在有无MG132处理下,用35S-Met/Cys标记追踪转染R6C/A24D的293T,INSAb-IP,SDS-PAGE分析2设计恢复n/c区正电荷的双突变R6C-M5R和R6C-D20R转染293T细胞,用35SCys/Met标记,INSAb-IP,SDS-PAGE分析3应用
Background and aims Dipeptidyl peptidase IV (DPP-IV),whose substrates includes glucagon-like peptide 1 and many other polypeptides, is not only important in pancreatic β-cell regulation but also has c
Background Inactivating MEN1 mutations are the most common genetic defects present in sporadic and inherited pancreatic neuroendocrine tumors (PNETs).The lack of interventional therapies prompted us t
Background and aims Pancreatic beta ceils undergo dynamic remodeling during neonatal period to meet the increased physiological demands after weaning, with decreased proliferation,neogenesis and enhan
Objectives Either metformin or GLP-1 analogue liraglutide,which is widely used in the therapy of type 2 diabetes (T2DM),has been shown to be potentially beneficial in the management of cardiovascular
Background Anemia is a common complication in patients with diabetes, and is often attributed to overt diabetic nephropathy or impaired renal function.Recently, the association of anemia and diabetic