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Recent advances in single nucleotide polymorphisms (SNPs) that allow genome-wide profiling of complex biological phenotypes have offered the golden opportunities to unravel the high-order mechanisms and have also motivated development of the corresponding analysis strategies.Several widely-used methods are based on the correlations between single molecular signature and phenotypes.But it is known that many complex human diseases such as behaviors of alcoholism are not simple Mendelian disorders.Instead,there may be mixed contributions of genes,environments and their interactions.An ideal measurement of correlations between molecular signatures and phenotypes should reflect both the signatures effects on phenotypes and its interactions with others.Here,we design a novel comprehensive criteria concerning both the informations of IBD statistic and genomic context.