TGF-β Sensitizes TRPV1 in Primary Sensory Neurons A Novel Mechanism for Rat Bone Cancer Pain

• 出 处: 上海市科学技术协会第十届学术年会——长三角地区神经科学论坛2012
• 发表日期: 2012年9期

　　During the progression of bone cancer, transforming growth factor-β (TGF-β) is released by osteoclast bone resorption, which contributes to proliferation, angiogenesis, immunosuppression, invasion and metastasis.Here, we further report that TGF-β1 is involved in bone cancer-induced thermal hyperalgesia via the upregulation and sensitization of the transient receptor potential vanilloid (TRPV1) in dorsal root ganglion (DRG) neurons in a rat model of bone cancer pain.