Tuning of Synthesis Conditions by Thermal Decomposition towards Gadolinium-doped Manganese Carbonate

• 作 者: Ting-jian Wang Kang Liu Xin Shi Ling Ye Wei Gu Chang-xiang Yan
• 机 构: Department of Neurosurgery,Sanbo Brain Hospital,Capital Medical University,Beijing 100093,P.R.China
• 出 处: 2016年磁共振技术暨纳米生物医学应用研讨会
• 发表日期: 2016年10期
• 关键词: Manganese carbonate nanoparticle gadolinium doping high relaxivity formation mec

　　Gd-doped MnCO3 nanoparticles(NPs)have been prepared by thermal decomposition of Mn-oleate with 20 mol%Gd-oleate at 310 ℃.However,MnCO3 tends to transform to MnO at temperature above 300 ℃.Developing thermal decomposition below 300 ℃ for the synthesis of MnCO3 NPs is therefore highly desirable.Herein,we testified the feasibility for the synthesis of Gd-doped MnCO3 NPs by the thermal decomposition method at low temperature of 280-300 ℃ and explored the effects of several parameters on the phase and uniformity of particles(figure 1).It was revealed that the Gd-doped MnCO3 NPs could be obtained only when the Gd doping concentration within a range of 20-33 mol%(figure 2),while the uniformity of resulting Gd-doped MnCO3 NPs could be improved either by elevating the reaction temperature or prolonging the aging time(figure 3).In addition,the formation mechanism of MnCO3 NPs with Gd doping was tentatively proposed based on the information acquired by thermogravimetric-gas chromatography-mass spectrometry(TG-GC-MS).Moreover,the obtained uniform-sized Gd-doped MnCO3 NPs present a high relaxivity and therefore hold great potential in serving as T1 contrast agents(figure 4).